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Phase II study of bleomycin, actinomycin D, DTIC and vindesine in disseminated malignant melanoma

✍ Scribed by Mulder, Nanno H.; Sleijfer, Dirk Th.; Smit, Jitty M.; de Vries, Elisabeth G.E.; Willemse, Pax H.B.; Schraffordt Koops, Heimen

Book ID
122943933
Publisher
Elsevier Science
Year
1986
Weight
294 KB
Volume
22
Category
Article
ISSN
0277-5379

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Phase II study: The combination DTIC, BC
Phase II study: The combination DTIC, BCNU, actinomycin D, and vincristine in disseminated malignant melanoma
✍ Creagan, E. T. ;Schutt, A. J. ;Long, H. J. ;Green, S. J. πŸ“‚ Article πŸ“… 1986 πŸ› John Wiley and Sons 🌐 English βš– 208 KB

Thirty patients with disseminated malignant melanoma received the combination DTIC, BCNU, actinomycin D, and vincristine. The objective response rate was 17 percent concornitant with moderate-to-severe nausea and vomiting in 80 percent of patients. Hematologic toxicity was transient. In the dose and