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Phase II evaluation of combination of mitomycin, cis-platinum and 5-FU in adenocarcinoma of the lung

Book ID
122536162
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
85 KB
Volume
2
Category
Article
ISSN
0169-5002

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Phase I clinical trial of combined thera
Phase I clinical trial of combined therapy with 5-FU (NSC 19893) and cis-platinum (II) diaminedichloride (NSC 119875)
✍ Richard A. Ellerby; Hugh L. Davis Jr.; Fred J. Ansfield; Guillermo Ramirez πŸ“‚ Article πŸ“… 1974 πŸ› John Wiley and Sons 🌐 English βš– 438 KB

Thirty-one loading courses of 5-FU and cis-platinum (11) diaminedichloride (CPD) were given to 27 patients with a variety of malignancies. Up to 16 mg/kg/day of 5-FU and 2.5 mg/kg of the platinum were reached with minimal toxicity. Nausea (27/31) and vomiting (23/31) were the most frequent symptoms,