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Phase II evaluation of chlorozotocin (NSC-178248) in advanced human cancer

✍ Scribed by Robert W. Talley; Michael K. Samson; Robert W. Brownlee; Ahmad M. Samhouri; Roberto J. Fraile; Laurence H. Baker

Book ID
113146686
Publisher
Elsevier Science
Year
1981
Weight
488 KB
Volume
17
Category
Article
ISSN
0014-2964

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Phase II evaluation of chlorozotocin in
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Twenty-nine evaluable patients with anthracycline-resistant metastatic bone or soft tissue sarcomas were treated with chlorozotocin, 150 mg/m2 every 6 weeks. Four patients (14%) achieved partial responses. The most severe toxicity was usually thrombocytopenia (which occurred in 31% of patients). Chl