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Phase II and pharmacokinetic/pharmacodynamic trial of sequential topoisomerase I and II inhibition with topotecan and etoposide in advanced non-small-cell lung cancer

✍ Scribed by Afshin Dowlati; Nathan Levitan; Nahida H. Gordon; Charles L. Hoppel; David M. Gosky; Scot C. Remick; Stephen T. Ingalls; Sossamma J. Berger; Nathan A. Berger

Publisher
Springer
Year
2001
Tongue
English
Weight
125 KB
Volume
47
Category
Article
ISSN
0344-5704

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## Abstract ## BACKGROUND Topotecan (9‐dimethylaminomethyl‐10‐hydroxycampthothecin) is a new topoisomerase I inhibitor with promising efficacy in the treatment of patients with small cell lung carcinoma (SCLC). Combination with a topoisomerase II inhibitor may potentate the therapeutic effect of t