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Phase I trial of the antifolate ZD9331 in combination with cisplatin in patients with refractory solid malignancies

✍ Scribed by JoshuaH. Bilenker; JamesP. Stevenson; KeithT. Flaherty; Kenneth Algazy; Kathy McLaughlin; DanielG. Haller; BruceJ. Giantonio; M. Koehler; J.E. Garcia-Vargas; PeterJ. O’Dwyer

Publisher
Springer
Year
2004
Tongue
English
Weight
166 KB
Volume
53
Category
Article
ISSN
0344-5704

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## Abstract ## BACKGROUND A Phase I study using weekly docetaxel and gemcitabine was conducted to investigate toxicity; to determine the maximum tolerated dose (MTD) of each agent; and, in a preliminary fashion, to determine the antitumor activity of the combination. ## METHODS Docetaxel and gem