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Phase I trial of strictly time-scheduled gemcitabine and cisplatin with concurrent radiotherapy in patients with locally advanced pancreatic cancer

✍ Scribed by Thomas B Brunner; Gerhard G Grabenbauer; Peter Klein; Ulrich Baum; Thomas Papadopoulos; Werner Bautz; Werner Hohenberger; Rolf Sauer

Book ID: 108435057
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 198 KB
Volume: 55
Category: Article
ISSN: 0360-3016
DOI: 10.1016/s0360-3016(02)03818-x

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## Background: Both twice daily fractionated radiotherapy and concurrent cisplatin with once-daily radiotherapy have been shown to improve local disease control in patients with head and neck cancer. the objective of this phase i trial was to determine the maximum tolerated dose of cisplatin which