Phase I trial of mitoxantrone and granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients with advanced solid malignancies
β Scribed by Joan H. Schiller; Barry Storer; Rhoda Arzoomanian; Kendra Tutsch; Dona Alberti; David Spriggs
- Publisher
- Springer US
- Year
- 1993
- Tongue
- English
- Weight
- 806 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0167-6997
No coin nor oath required. For personal study only.
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## BACKGROUND. Both paclitaxel and mitoxantrone demonstrate significant antineoplastic activity in breast cancer patients. Colony stimulating factor support allows significant dose escalation of each of these drugs when administered as a single agent. ## METHODS. We performed a Phase I study empl
## BACKGROUND. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine that is involved in the differentiation and proliferation of various hematopoietic precursors. It also has been reported to enhance the antitumor activity of various mature effector cells. Previous reports have