Phase I trial of 5-fluorouracil by 24-hour infusion weekly
β Scribed by N. B. Haas; J. B. Hines; G. R. Hudes; N. Johnston; R. F. Ozols; P. J. O'Dwyer
- Publisher
- Springer US
- Year
- 1993
- Tongue
- English
- Weight
- 397 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0167-6997
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## BACKGROUND. Reports of in vitro experiments in colorectal carcinoma cells suggest that prolonged cellular exposure to 5-fluorouracil (5-FU) combined with relatively low concentrations of leucovorin (LV) provides optimal enhancement of 5-FU efficacy. In this study, a simplified regimen of weekly
Background. In a previous Phase I1 trial, the authors showed that a weekly continuous infusion of 5-fluorouracil (5-FU) at a dose of 3.5 g/mz for 48 hours is an active treatment for advanced colorectal cancer. The overall response rate was 38.5%, and the median survival was 12 months. These data wer