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Phase I study with neocarzinostatin. Tolerance to two hour infusion and continuous infusion

✍ Scribed by Takao Ohnuma; Christopher Nogeire; Janet Cuttner; James F. Holland

Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
772 KB
Volume
42
Category
Article
ISSN
0008-543X

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Fourty-four evaluable patients were treated with 6-methylmercaptopurine riboside (MMPR) at a dose of 20 mg/m2/day X 5 by continuous IV infusion (days 1-5 and 5-fluorouracil (5-FU) on an escalating dose schedule of 300-1519 mg/m2/day X 5 by continuous IV infusion (days 2-6). Dose-limiting oral mucosi