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Phase I study of the oral mammalian target of rapamycin inhibitor everolimus (RAD001) in Japanese patients with relapsed or refractory non-Hodgkin lymphoma

✍ Scribed by Kensei Tobinai; Michinori Ogura; Dai Maruyama; Toshiki Uchida; Naokuni Uike; Ilseung Choi; Kenichi Ishizawa; Kuniaki Itoh; Kiyoshi Ando; Masafumi Taniwaki; Naomi Shimada; Ken Kobayashi


Book ID
107619154
Publisher
Carden Jennings Publishing
Year
2010
Tongue
English
Weight
345 KB
Volume
92
Category
Article
ISSN
0925-5710

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## Abstract ## BACKGROUND: Dysregulation of phosphatase and tensin homolog (PTEN) and the gene that encodes the p110Ξ± catalytic subunit of phosphatidylinositol‐3‐kinase (PI3K), PIK3CA, are the most common mutations in endometrial carcinoma (EC). Loss of PTEN or activation of PIK3CA results in cons