## Abstract ## BACKGROUND Metastatic melanoma (MM) is associated with a high risk of central nervous system (CNS) metastases, and current chemotherapy does not adequately treat or protect patients with MM against CNS metastases. Therefore, the authors initiated a Phase I study to determine the pha
Phase I study of the combination of docetaxel, temozolomide and cisplatin in patients with metastatic melanoma
โ Scribed by Kevin B. Kim; Wen-Jen Hwu; Nicholas E. Papadopoulos; Agop Y. Bedikian; Luis H. Camacho; Chaan Ng; Ingrid M. Hernandez; Angela M. Frost; Monica A. Jack; Patrick Hwu
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 268 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0344-5704
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
by 40 mg to the MTD in groups of 3 patients. DDP (80 mg/m 2 ) was begun on Day ogy/Oncology, Hollings Cancer Center, Medical 2 and repeated weekly for a total of 3 weeks. During Week 4, the patients were University of South Carolina, Charleston, South not treated with DDP but instead evaluated for r
A Phase I study was initiated to determine the maximum tolerated dose of weekly gemcitabine combined with monthly, fixed-dose docetaxel. ## METHODS. Patients with metastatic solid tumors were treated with docetaxel, 60 mg/m 2 , on Day 1 every 28 days. Gemcitabine was administered on Days 1, 8, and