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Phase I study of recombinant human tumor necrosis factor

✍ Scribed by Kiyoji Kimura; Tetsuo Taguchi; Ichiro Urushizaki; Ryuzo Ohno; Osahiko Abe; Hisashi Furue; Takao Hattori; Hidehito Ichihashi; Kiyoshi Inoguchi; Hisashi Majima; Hisanobu Niitani; Kazuo Ota; Tatsuo Saito; Shoji Suga; Yozo Suzuoki; Akira Wakui; Kazumasa Yamada

Publisher
Springer
Year
1987
Tongue
English
Weight
660 KB
Volume
20
Category
Article
ISSN
0344-5704

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Phase I study of recombinant human tumor
Phase I study of recombinant human tumor necrosis factor Ξ± in advanced malignant disease
✍ T. Moritz; N. Niederle; J. Baumann; D. May; E. Kurschel; R. Osieka; J. Kempeni; πŸ“‚ Article πŸ“… 1989 πŸ› Springer-Verlag 🌐 English βš– 643 KB

A phase I study withrecombinant human tumor necrosis factor a (rhuTNF-a; Knoll AG, Ludwigshafen, FRG) in patients with advanced malignant disease was undertaken to evaluate drug toxicity (organ specifity, time course, predictability, reversibility, maximal tolerated dose), effectiveness, antigenicit