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Phase I study of cladribine, cytarabine, granulocyte colony stimulating factor (CLAG regimen) and midostaurin and all-transretinoic acid in relapsed/refractory AML

✍ Scribed by Ramsingh, Giridharan; Westervelt, Peter; McBride, Ali; Stockerl-Goldstein, Keith; Vij, Ravi; Fiala, Mark; Uy, Geoffrey; Cashen, Amanda; DiPersio, John F.; Abboud, Camille N.


Book ID
121533721
Publisher
Carden Jennings Publishing
Year
2014
Tongue
English
Weight
345 KB
Volume
99
Category
Article
ISSN
0925-5710

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Phase I study of cladribine, cytarabine
✍ Alison R. Walker; Rami S. Komrokji; Jainulabdeen Ifthikharuddin; Patti Messina; πŸ“‚ Article πŸ“… 2008 πŸ› Elsevier Science 🌐 English βš– 208 KB

Receptor activated tyrosine kinases such as c-kit, c-fms and PDGFR are known targets of inhibition by imatinib mesylate (Gleevec) and are expressed on AML blasts. Marrow stromal cells and monocytes express KIT ligand, M-CSF and PDGF and are therefore capable of activating survival pathways in these