Phase I study of cladribine, cytarabine
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Alison R. Walker; Rami S. Komrokji; Jainulabdeen Ifthikharuddin; Patti Messina;
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Article
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2008
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Elsevier Science
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English
β 208 KB
Receptor activated tyrosine kinases such as c-kit, c-fms and PDGFR are known targets of inhibition by imatinib mesylate (Gleevec) and are expressed on AML blasts. Marrow stromal cells and monocytes express KIT ligand, M-CSF and PDGF and are therefore capable of activating survival pathways in these