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Phase-I study of a new schedule based on increasing days of topotecan administration associated with dose individualisation

✍ Scribed by Jean-Pierre Delord; Frédéric Léger; Pierre Canal; Muriel Poublanc; Roland Bugat; Etienne Chatelut

Publisher
Springer
Year
2005
Tongue
English
Weight
234 KB
Volume
58
Category
Article
ISSN
0344-5704

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## Abstract ## BACKGROUND Based on preclinical findings and on the clinical antitumor efficacy of sequential paclitaxel/topotecan and topotecan/etoposide, the authors sought to define the maximum tolerated doses (MTDs) and dose‐limiting toxicities (DLTs) associated with a sequential combination of