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Phase I clinical trial of cisplatin given i.v. with 5-fluorouracil and high-dose folinic acid

✍ Scribed by James L. Abbruzzese; Robert Amato; Susan Schmidt; Martin N. Raber; Philip Frost


Book ID
105645883
Publisher
Springer
Year
1990
Tongue
English
Weight
403 KB
Volume
26
Category
Article
ISSN
0344-5704

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Background. Metastatic colorectal cancer is generally incurable. The most active regimen available, 5-fluorouracil(5-FU) and folinic acid (Leucovorin), produces response rates of approximately 25% to 30%. Methyl-lomustine is a nitrosourea with modest activity against colorectal cancer. A randomized