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Phase I clinical study of nafazatrom

โœ Scribed by Gabriel N. Hortobagyi; Nicholas E.J. Papadoupoulos; Debra Frye; Jaffer Ajani; James M. Reuben


Publisher
Springer US
Year
1986
Tongue
English
Weight
341 KB
Volume
4
Category
Article
ISSN
0167-6997

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Phase I and pharmacologic evaluation of
โœ Charles D. Haas; Laurence H. Baker; Llewelyn J. Evans ๐Ÿ“‚ Article ๐Ÿ“… 1984 ๐Ÿ› Springer US ๐ŸŒ English โš– 306 KB

Nafazatrom was evaluated in escalating daily oral doses ranging from 0.25 to 8.0 g/m 2 without producing significant toxicities. Malabsorption proved dose limiting at 8.0 g/m 2 as a single daily dose, but splitting the same total dose into two or four doses circumvented this problem. Doses of 2.0 g/