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Phase I clinical and pharmacokinetic study of oral 9-aminocamptothecin (NSC-603071)

✍ Scribed by Sridhar Mani; Lalitha Iyer; Linda Janisch; Xiaolin Wang; Gini F. Fleming; Richard L. Schilsky; Mark J. Ratain

Publisher
Springer
Year
1998
Tongue
English
Weight
371 KB
Volume
42
Category
Article
ISSN
0344-5704

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Eflornithine-HCl (alpha-difluoromethylornithine or DFMO), an irreversible inhibitor of ornithine decarboxylase, blocks polyamine synthesis and has demonstrated antitumor activity in cell culture and animal tumor models. This phase I study was designed to determine and compare toxicity and the maxima