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Phase I and pharmacokinetic study of SPI-77, a liposomal encapsulated dosage form of cisplatin

✍ Scribed by Jetske M. Meerum Terwogt; Gerard Groenewegen; Dick Pluim; Marc Maliepaard; Matthijs M. Tibben; Albert Huisman; Wim W. ten Bokkel Huinink; Margaret Schot; Helen Welbank; Emile E. Voest; Jos H. Beijnen; Jan H. Schellens


Publisher
Springer
Year
2002
Tongue
English
Weight
166 KB
Volume
49
Category
Article
ISSN
0344-5704

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## BACKGROUND. Compared with free drug, sterically stabilized liposomal drug has prolonged circulation time and, thereby, higher tumor selectivity and antitumor activity. The stability in plasma is an important consideration in the formulation of clinically useful liposomal drug. A Phase I study o

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## Abstract ## BACKGROUND OSI‐211 is a low‐clearance, unilamellar liposomal formulation of a water‐soluble camptothecin analogue, lurtotecan. OSI‐211 has significant activity in severe combined immunodeficient mouse models of human leukemia. ## METHODS This study was conducted to define the dose