Phase I and pharmacokinetic study of SPI-77, a liposomal encapsulated dosage form of cisplatin
β Scribed by Jetske M. Meerum Terwogt; Gerard Groenewegen; Dick Pluim; Marc Maliepaard; Matthijs M. Tibben; Albert Huisman; Wim W. ten Bokkel Huinink; Margaret Schot; Helen Welbank; Emile E. Voest; Jos H. Beijnen; Jan H. Schellens
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 166 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0344-5704
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π SIMILAR VOLUMES
by 40 mg to the MTD in groups of 3 patients. DDP (80 mg/m 2 ) was begun on Day ogy/Oncology, Hollings Cancer Center, Medical 2 and repeated weekly for a total of 3 weeks. During Week 4, the patients were University of South Carolina, Charleston, South not treated with DDP but instead evaluated for r
## BACKGROUND. Compared with free drug, sterically stabilized liposomal drug has prolonged circulation time and, thereby, higher tumor selectivity and antitumor activity. The stability in plasma is an important consideration in the formulation of clinically useful liposomal drug. A Phase I study o
## Abstract ## BACKGROUND OSIβ211 is a lowβclearance, unilamellar liposomal formulation of a waterβsoluble camptothecin analogue, lurtotecan. OSIβ211 has significant activity in severe combined immunodeficient mouse models of human leukemia. ## METHODS This study was conducted to define the dose