Phase diagrams of bilayers of dimyristoyl lecithin plus heteroacid lecithins

✍ Scribed by P.J. Davis; K.M.W. Keough

• Publisher: Elsevier Science
• Year: 1984
• Tongue: English
• Weight: 482 KB
• Volume: 35
• Category: Article
• ISSN: 0009-3084
• DOI: 10.1016/0009-3084(84)90072-0

✦ Synopsis

Aqueous dispersions of dimyristoyl phosphatidylcholine (DMPC) mixed with 1-palmitoyl-2-oleoyl phosphatidylcholine (POPC) or with 1-palmitoyl-2-stearoyl phosphatidylcholine (PSPC) have been studied by differential scanning calorimetry. Analysis of phase diagrams of the resulting bilayers indicated that both POPC-DMPC were miscible, but not ideally mixed, in the gel and in the liquid-crystalline states. In both states, estimated values for excess interaction energies were more positive for PSPC-DMPC than for POPC-DMPC, indicating that mixing was less ideal in the former system.