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Phase 2 trial of talampanel, a glutamate receptor inhibitor, for adults with recurrent malignant gliomas

✍ Scribed by Fabio M. Iwamoto; Teri N. Kreisl; Lyndon Kim; J. Paul Duic; John A. Butman; Paul S. Albert; Howard A. Fine


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
175 KB
Volume
116
Category
Article
ISSN
0008-543X

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## BACKGROUND. Efforts to improve local control and survival by increasing the dose of once-daily radiation therapy beyond 70 Gray (Gy) for patients with malignant gliomas have as yet been unsuccessful. Hyperfractionated radiation therapy (HF) should allow for delivery of a higher total dose witho