Phase 1/2 clinical study of dasatinib in Japanese patients with chronic myeloid leukemia or Philadelphia chromosome-positive acute lymphoblastic leukemia
β Scribed by Hisashi Sakamaki; Ken-ichi Ishizawa; Masafumi Taniwaki; Shin Fujisawa; Yasuo Morishima; Kensei Tobinai; Masaya Okada; Kiyoshi Ando; Noriko Usui; Shuichi Miyawaki; Atae Utsunomiya; Nobuhiko Uoshima; Tadashi Nagai; Tomoki Naoe; Toshiko Motoji; Itsuro Jinnai; Mitsune Tanimoto; Yasushi Miyazaki; Kazunori Ohnishi; Shinsuke Iida; Shinichiro Okamoto; Taku Seriu; Ryuzo Ohno
- Book ID
- 107618711
- Publisher
- Carden Jennings Publishing
- Year
- 2009
- Tongue
- English
- Weight
- 195 KB
- Volume
- 89
- Category
- Article
- ISSN
- 0925-5710
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π SIMILAR VOLUMES
## Abstract ## BACKGROUND: Nilotinib is a selective, potent BCRβABL inhibitor. Previous studies demonstrated the efficacy and safety of nilotinib in Philadelphia chromosomeβpositive chronic myeloid leukemia patients in chronic phase (CMLβCP) or accelerated phase who failed prior imatinib. ## METH
We report the sublocalization of the breakpoint in chromosome 22 in 33 patients with chronic myeloid leukemia (CML) who also had unusual marrow cytogenetics. In 23 patients, the leukemic clones were characterized by Philadelphia (Ph') chromosomes that arose through complex translocations that involv