## Abstract ## BACKGROUND A prospective, singleβarm, openβlabel, nonrandomized Phase 2 study of combined fludarabine and mitoxantrone (FM) plus radioimmunotherapy was conducted to evaluate efficacy and safety in patients with untreated, indolent, nonfollicular nonβHodgkin lymphoma (NHL). ## METHO
Phase 1 trial of bortezomib plus R-CHOP in previously untreated patients with aggressive non-Hodgkin lymphoma
β Scribed by Richard R. Furman; Peter Martin; Jia Ruan; Ying-Kuen K. Cheung; Julie M. Vose; Ann S. LaCasce; Rebecca Elstrom; Morton Coleman; John P. Leonard
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 169 KB
- Volume
- 116
- Category
- Article
- ISSN
- 0008-543X
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π SIMILAR VOLUMES
Ifosfamide (1.25 g/m2 intravenously/day x 5) with mesna (20% of the ifosfamide dose x six doses on each day of ifosfamide therapy) was administered to 46 previously treated patients with non-Hodgkin's lymphoma of which 31 were eligible and evaluable. A 29% response rate (9/31) was observed (2 CR and
## Abstract Ifosfamide (2.0 g/m^2^ intravenously/day Γ 3) with mesna (400 mg/m^2^ intravenously q 4 h daily Γ 3) was combined with mitoxantrone (14 mg/m^2^ intravenously Γ 1) and given on a 3 week schedule to patients with previously treated nonβHodkgin's lymphoma. In 45 eligible/evaluable patients