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Phase 1 study of PTK787/ZK 222584, a small molecule tyrosine kinase receptor inhibitor, for the treatment of acute myeloid leukemia and myelodysplastic syndrome

✍ Scribed by Roboz, G J; Giles, F J; List, A F; Cortes, J E; Carlin, R; Kowalski, M; Bilic, S; Masson, E; Rosamilia, M; Schuster, M W


Book ID
110056732
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
120 KB
Volume
20
Category
Article
ISSN
0887-6924

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## Abstract ## BACKGROUND: The authors conducted a phase 1/2 study of tipifarnib in combination with idarubicin and cytarabine (IA) in 95 patients with previously untreated acute myeloid leukemia (AML) or high‐risk myelodysplastic syndrome. ## METHODS: Induction consisted of idarubicin 12 mg/m^2