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Phase 1 multicenter study of vincristine sulfate liposomes injection and dexamethasone in adults with relapsed or refractory acute lymphoblastic leukemia

✍ Scribed by Deborah A. Thomas; Hagop M. Kantarjian; Wendy Stock; Leonard T. Heffner; Stefan Faderl; Guillermo Garcia-Manero; Alessandra Ferrajoli; William Wierda; Sherry Pierce; Biao Lu; Steven R. Deitcher; Susan O'Brien

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 142 KB
Volume: 115
Category: Article
ISSN: 0008-543X
DOI: 10.1002/cncr.24632

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## Abstract ## BACKGROUND. The authors evaluated the response rate, toxicity, and pharmacokinetics of topotecan given before standard induction therapy for childhood acute lymphoblastic leukemia (ALL) in first relapse. ## METHODS. Patients received topotecan (2.4 mg/m^2^ daily as a 30‐minute inf