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Phase 1 and pharmacokinetic study of everolimus, a mammalian target of rapamycin inhibitor, in combination with docetaxel for recurrent/refractory nonsmall cell lung cancer

✍ Scribed by Suresh S. Ramalingam; R. Donald Harvey; Nabil Saba; Taofeek K. Owonikoko; John Kauh; Dong M. Shin; Shi-Yong Sun; Sandra Strychor; Mourad Tighiouart; Merrill J. Egorin; Haian Fu; Fadlo R. Khuri


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
151 KB
Volume
116
Category
Article
ISSN
0008-543X

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## Abstract ## BACKGROUND: Dysregulation of phosphatase and tensin homolog (PTEN) and the gene that encodes the p110Ξ± catalytic subunit of phosphatidylinositol‐3‐kinase (PI3K), PIK3CA, are the most common mutations in endometrial carcinoma (EC). Loss of PTEN or activation of PIK3CA results in cons