Pharmacology of mitoxantrone: mode of action and pharmacokinetics
โ Scribed by David S. Alberts; Yei Mei Peng; G. Timothy Bowden; William S. Dalton; Cindy Mackel
- Publisher
- Springer US
- Year
- 1985
- Tongue
- English
- Weight
- 522 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0167-6997
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Mitoxantrone 5 -6 mg/m 2 was administered IV to 10 consenting patients prior to surgical resection of an intracerebral tumor. Plasma pharmacokinetic parameters were calculated and concentration of mitoxantrone in intracerebral tumors was determined. Concentrations of mitoxantrone were also determine
The objective of this investigation was to compare the observed biliary clearance (CL(b)) and % of dose excreted in the bile (PD(b)) of mitoxantrone with the predicted values obtained from quantitative structure pharmacokinetic relationship (QSPKR) models. Blood and bile samples were collected from
An HPLC method using paired-ion chromatography on RP C-18 material was developed. After sample clean up on XAD columns, mitoxantrone (Novantrone; dihydroxyanthracenedione) in concentrations below 1 ng/ml in serum and 0.2 ng/ml in urine were measurable with a coefficient of variation less than 9.3% a