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Pharmacology of MEN 11467: a potent new selective and orally- effective peptidomimetic tachykinin NK1 receptor antagonist

✍ Scribed by R. Cirillo; M. Astolfi; B. Conte; G. Lopez; M. Parlani; G. Sacco; R. Terracciano; C.I. Fincham; A. Sisto; S. Evangelista; C.A. Maggi; S. Manzini


Book ID
114484913
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
183 KB
Volume
35
Category
Article
ISSN
0143-4179

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## Abstract The airways' pharmacology of DNK333 ((1R,3R,2E)‐N‐[3,4‐dichlorobenzyl)]‐4‐[(hexahydro‐2‐oxo‐1H‐azepin‐3‐yl)amino]‐N‐methyl‐3,5bis(trifluoromethyl) benzamide), a potent and selective dual NK~1~/NK~2~ neurokinin receptor antagonist is described in the present paper. DNK333 bound with high