𝔖 Bobbio Scriptorium
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Pharmacology and toxicology of phosphorothioate oligonucleotides in the mouse, rat, monkey and man

✍ Scribed by Patrick L. Iversen; Bryan L. Copple; Hemant K. Tewary


Book ID
118411976
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
615 KB
Volume
82-83
Category
Article
ISSN
0378-4274

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## Abstract **BACKGROUND:** Fetal uptake of an antisense oligonucleotide was evaluated after intravenous (i.v.) dosing of ISIS 2105, a 20‐base phosphorothioate oligonucleotide, in timed‐pregnant Sprague‐Dawley rats. **METHODS:** To maximize the potential for fetal exposure, ISIS 2105 was administer