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Pharmacologically elevated levels of endogenous kynurenic acid prevent nicotine-induced activation of nigral dopamine neurons

✍ Scribed by Sophie Erhardt; Helena Öberg; Göran Engberg


Publisher
Springer-Verlag
Year
2001
Tongue
English
Weight
120 KB
Volume
363
Category
Article
ISSN
0028-1298

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The present electrophysiological study shows that manipulation with endogenous brain kynurenic acid (KYNA) is able to affect the response of central noradrenergic neurons to nicotine. Previous studies have shown that systemically administered nicotine in low doses is associated with a marked, but sh