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Pharmacological Modulation of Peripheral T and B Lymphocytes by a Selective Sphingosine 1-Phosphate Receptor-1 Modulator

✍ Scribed by Moberly, James B.; Rohatagi, Shashank; Zahir, Hamim; Hsu, Ching; Noveck, Robert J.; Truitt, Kenneth E.

Book ID
118261286
Publisher
Sage Publications
Year
2012
Tongue
English
Weight
375 KB
Volume
52
Category
Article
ISSN
0091-2700

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## Abstract Thymic development requires proliferation, selection, maturation and release of mature single‐positive CD4 and CD8 T cells into the periphery. In mice, non‐selective sphingosine‐1 phosphate (S1P) receptor agonists, active on four of the five known S1P receptors, alter thymocyte phenotyp