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Pharmacological modulation of fatty acid desaturation and of cholesterol biosynthesis in THP-1 cells

✍ Scribed by P. Risé; S. Ghezzi; M. G. Levati; R. Mirtini; C. Colombo; C. Galli

Book ID
107485341
Publisher
Springer-Verlag
Year
2003
Tongue
English
Weight
111 KB
Volume
38
Category
Article
ISSN
0024-4201

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We investigated the effects of medium supplementation with increasing amounts of different fatty acids on HepG2 cell cholesterol biosynthesis and esterification. Up to 200 ~M 16:0 led to an increase in cholesterol secretion/synthesis of 60%/40%; 18:1, 18:2, or 18:3 decreased secretion/synthesis by 3