Pharmacological modifications of the partial pressure of oxygen in murine tumors: Evaluation using in vivo EPR oximetry

✍ Scribed by Bernard Gallez; Bénédicte F. Jordan; Christine Baudelet; Pierre-Damien Misson

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 68 KB
• Volume: 42
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/(sici)1522-2594(199910)42:4<627::aid-mrm2>3.0.co;2-m

✦ Synopsis

EPR oximetry using an implantable paramagnetic probe was used to quantify the partial pressure of oxygen (pO 2 ) in tissues in a transplantable mouse tumor model (TLT) after administration of 34 different vasodilators belonging to one of the following classes: angiotensin-converting enzyme inhibitors, calcium antagonists, alpha antagonists, potassium channel openers, beta-blockers, NO donors, and peripheral vasoactive agents. Twenty-four compounds were efficient in significantly increasing the local pO 2 in a majority of tumors. The increase of local pO 2 using pharmacological treatments was lower than that achieved by using oxygen or carbogen breathing. This technique offers an unprecedented tool for rapidly and accurately measuring treatment-induced modifications of pO 2 in tumors.