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Pharmacological Mechanisms of Naltrexone and Acamprosate in the Prevention of Relapse in Alcohol Dependence

✍ Scribed by John Littleton; Walter Zieglgänsberger

Book ID
109061634
Publisher
Informa plc
Year
2003
Tongue
English
Weight
101 KB
Volume
12
Category
Article
ISSN
1055-0496

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## Abstract ## Introduction Oxcarbazepine (OXC) reduces high‐voltage‐activated calcium currents, thus reducing glutamatergic transmission at corticostriatal synapses. This effect on NMDA glutamatergic transmission may play a role against the increased glutamatergic transmission determined by alcoh