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Pharmacological inhibition of inducible nitric oxide synthase attenuates the development of seizures in mice

โœ Scribed by Ashish K. Rehni; Thakur Gurjeet Singh; Rohit Kalra; Nirmal Singh


Book ID
116790763
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
319 KB
Volume
21
Category
Article
ISSN
1089-8603

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We assessed the effects of N(omega)-nitro-L-arginine-methyl ester (L-NAME), an inhibitor of nitric oxide synthase (NOS), on behavioral and electrographic seizures elicited in mice by convulsant doses of kainate. In Expt. 1, L-NAME dose-dependently potentiated the convulsant effects of kainate (44 mg