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Pharmacological inhibition of AKT sensitizes MCF-7 human breast cancer-initiating cells to radiation

✍ Scribed by Jun-Fang Zhan; Liang-Ping Wu; Long-Hua Chen; Ya-Wei Yuan; Guo-Zhu Xie; Ai-Min Sun; Ying Liu; Zhi-Xian Chen


Book ID
107702465
Publisher
Springer Netherlands
Year
2011
Tongue
English
Weight
210 KB
Volume
34
Category
Article
ISSN
1570-5870

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## Abstract We reported recently that roscovitine (ROSC), a selective cyclin‐dependent kinase (CDK) inhibitor, arrests human MCF‐7 breast cancer cells in G~2~ phase of the cell cycle, and concomitantly induces apoptosis. Human MCF‐7 breast cancer cells are known to express elevated levels of c‐Ha‐R