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Pharmacological evidence for the involvement of the cAMP cascade in sensory fatigue inDrosophila

โœ Scribed by Gabriel Corfas; Yadin Dudai

Publisher
Springer
Year
1990
Tongue
English
Weight
448 KB
Volume
167
Category
Article
ISSN
0340-7594

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โœฆ Synopsis

We have investigated the effect of systemic treatment with drugs that affect the cAMP cascade on the sensory response and sensory fatigue in an identified mechanosensory neuron of Drosophila. Forskolin, an activator of adenylate cyclase, decreases the sensory response of the neuron. H7, an inhibitor of protein kinase, inhibits sensory fatigue. Octopaminergic ligands facilitate sensory fatigue. These results, together with our previous neurogenetic analysis of sensory fatigue in Drosophila (Corfas and Dudai 1990), corroborate the hypothesis that the cAMP cascade is involved in the generation and modulation of sensory fatigue.

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