Pharmacological effects of some 6-azauracil derivatives
✍ Scribed by M. Timar; S. Sauvard; A. Botez; M. Simionovici; D. Winter; C.M. Georgescu; C. Cristescu; Th. Panaitescu
- Book ID
- 115769334
- Publisher
- Elsevier Science
- Year
- 1966
- Tongue
- English
- Weight
- 168 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0006-2952
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## Abstract By diazotization of 3‐(2‐aminophenyl)‐1,2‐dihydroquinoxaline 1c, its 3‐(4‐aminophenyl)‐isomer**2c**, 3‐(2‐aminobenzyl)‐1,2‐dihydroquinoxaline‐2‐one **3c** and its 3‐(4‐aminobenzyl)‐isomer **4c** and by azo coupling of formed diazonium salts with ethyl cyanoacetylcarbamate, corresponding
21008C with and without an electrophilic agent. Reactions of appropriate 6-azauracils with t-butyllithium and lithium diisopropylamide gave, as a result of a ring contraction, compounds 5 and 6. The structure of compound 5 was undeniably established by X-ray analysis. A mechanism of the novel ring t
In spite of the fact that a great number of several 4-substituted derivatives of phenazone has already been prepared, the only derivative with 6-azauracile cycle up to now is 4-(2-thio-6-azauraciI-5-yl)-phenazone, prepared by Schmid?'.