Pharmacological effects of paniculatin—a glycoside isolated from ipomoea digitata linn
✍ Scribed by M. A. Matin; J. P. Tewari; D. K. Kalani
- Publisher
- John Wiley and Sons
- Year
- 1969
- Tongue
- English
- Weight
- 801 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
A glycoside (paniculatin), m.p. 134", CaoHs.rO13 has been isolated from the tubers of Ipomoea digitutu Linn. It elevated the blood pressure, showed a stimulant effect on myocardium and respiration, a vasoconstrictor and bronchoconstrictor effect, a spasmogenic effect on smooth muscles of gut, and also an oxytocic activity. The LDso (48 hr.), with 95 % fiducial limits, was found to be 867.4 (755.3-985.1) mg./kg. (SE f 1.03) intraperitoneally in mice. Keyphrases 0 Paniculatin-Ipomoea digitatu glycoside 0 Pharmacological screening-paniculatin 0 LDm value-paniculatin ACKNOWLEDGMENTS AND ADDRESSES