Pharmacological effects of Hoe 249: A new potential antidepressant

✍ Scribed by Hans Georg Alpermann; Ulrich Schacht; Patricia Usinger; Franz J. Hock

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 845 KB
• Volume: 25
• Category: Article
• ISSN: 0272-4391
• DOI: 10.1002/ddr.430250403

✦ Synopsis

The 1 -(2-hydroxy-1 -phenylethyl)-imidazole derivative Hoe 249 has a profile which suggests the compound is a promising candidate for clinical evaluation as an antidepressant drug. In pharmacological tests commonly considered predictive of antidepressant activity, e.g., reserpine-and tetrabenazine-antagonism, reversal of oxotremorine-and apomorphine-induced hypothermia, and potentiation of yohimbine toxicity, Hoe 249 is equipotent to nomifensine, but does not meet excitation and stereotypic behavior in a comparable dose range. Hoe 249 shows weak anticonvulsant activity against pentylenetetrazole-induced seizures and it causes a slight dose-dependent prolongation of hexobarbital narcosis. Biochemical studies characterize Hoe 249 as an inhibitor of synaptosomal dopamine and norepinephrine uptake, whereas serotonin uptake is not influenced.