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Pharmacological characterization of the physostigmine stimulus in rats

✍ Scribed by M. Jung; A. Perio; P. Worms; P. Soubrie

Publisher: Springer
Year: 1988
Tongue: English
Weight: 249 KB
Volume: 95
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00172975

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✦ Synopsis

Rats were trained to discriminate 0.10 mg/kg SC physostigmine from saline in a two-lever food-reinforced task. There was generalization to the acetylcholine esterase inhibitor THA as well as to the muscarinic receptor agonists arecoline, oxotremorine and RS 86, but not to neostigmine or nicotine. The physostigmine cue was blocked by SC scopolamine hydrobromide and by ICV pirenzepine, but not by scopolamine methylbromide or by mecamylamine. These antagonism studies suggest that the discriminative cue elicited by physostigmine might be mainly mediated by central M1 receptors.

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