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Pharmacological characterization of a 1,4-dihydropyridine analogue, 9-(3,4-dichlorophenyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydro-1,8(2H,5H)-acridinedione (A-184209) as a novel KATP channel inhibitor

โœ Scribed by Murali Gopalakrishnan; Thomas R Miller; Steven A Buckner; Ivan Milicic; Eduardo J Molinari; Kristi L Whiteaker; Rachel Davis-Taber; Victoria E Scott; Christopher Cassidy; James P Sullivan; William A Carroll


Book ID
110007608
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
176 KB
Volume
138
Category
Article
ISSN
0007-1188

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The asymmetric unit of the title compound, C~22~H~29~N~3~O~5~S, contains two independent molecules, __A__ and __B__, which differ slightly in the orientation of the ethyl and tosyl groups with respect to the attached pyrrolidine ring, as evidenced by the relevant torsion angles. In both molecules, t