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Pharmacological chaperone therapy for Gaucher disease: a patent review

✍ Scribed by Benito, Juan M; García Fernández, José M; Mellet, Carmen Ortiz

Book ID
111880757
Publisher
Informa plc
Year
2011
Tongue
English
Weight
819 KB
Volume
21
Category
Article
ISSN
1354-3776

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## Abstract A series of __O__‐alkyl iminoxylitol derivatives was synthesized and evaluated as β‐glucocerebrosidase (GCase) inhibitors. This structure–activity study shows a dramatic influence of the position of the alkyl chain (α‐C1, O2, O3, or O4) on human GCase inhibition. Remarkably, 1,2‐shift o