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Pharmacological and behavioral characterization of cocaine-kindled seizures in mice

โœ Scribed by K. A. Miller; J. M. Witkin; J. T. Ungard; M. Gasior


Publisher
Springer
Year
2000
Tongue
English
Weight
86 KB
Volume
148
Category
Article
ISSN
0033-3158

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We assessed the effects of N(omega)-nitro-L-arginine-methyl ester (L-NAME), an inhibitor of nitric oxide synthase (NOS), on behavioral and electrographic seizures elicited in mice by convulsant doses of kainate. In Expt. 1, L-NAME dose-dependently potentiated the convulsant effects of kainate (44 mg