Pharmacologic study of norcaperatic and agaricic acids

✍ Scribed by Richard A. Carrano; Marvin H. Malone

• Publisher: John Wiley and Sons
• Year: 1967
• Tongue: English
• Weight: 381 KB
• Volume: 56
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600561216

✦ Synopsis

were comparatively smaller presumably due to further oxidative degradation of the five-membered heterocyclic ring carrying the epoxy group.

Ecgonine and Cocaine-Ecgonine is a carboxy derivative of tropanol, while cocaine is a carbomethoxy derivative of tropanyl benzoate. Although these compounds would be expected to yield the same products of degradation, the yield of six-membered heterocyclic compounds was in fact, very poor (Fig. l,E andF). Presumably these compounds do not decarboxylate easily and are retained by the basic support.

Conclusions

The experimental data reported above demonstrate that the described technique should prove of value in establishing the identity of tropane alkaloids as well as in recognizing the tropane carbon skeleton in alkaloids of unknown structure. REFERENCES (1) Nigam, I. C.,