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Pharmacologic Properties and Clinical Evaluation of the New Inotropic Agent OPC-8212 (Vesnarinone)

✍ Scribed by Feldman, Arthur M.


Book ID
109105884
Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
720 KB
Volume
11
Category
Article
ISSN
0897-5957

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✍ Maria Novella Romanelli; Alessandro Bartolini; Carlo Bertucci; Silvia Dei; Carla πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 527 KB

The enantiomers of 3-a-tropyl 2-(phenylthio) butyrate (SMT2, 1 ) were prepared by chiral synthesis and tested for analgesic, cognition-enhancing, and ACh-releasing properties. They show enantioselectivity in some of the tests, the eutomer being related in configuration to R-( +)-hyoscyamine.