tent of AST despite increasing serum levels of the enzyme. Such increased tissue levels of AST in animals despite increased serum levels after injury have been noted before and only unsatisfactorily explained, as perhaps reflecting rapid resynthesis of enzyme after leakage. This study is of clinical
Pharmacologic manipulation of graft versus host induced splenomegaly
✍ Scribed by R. E. Roudebush; H. U. Bryant
- Publisher
- SP Birkhäuser Verlag Basel
- Year
- 1992
- Tongue
- English
- Weight
- 536 KB
- Volume
- 35
- Category
- Article
- ISSN
- 1420-908X
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Graft-versus-host disease (GVHD) has been the primary limitation to the wider application of allogeneic bone marrow transplantation (BMT). The pathophysiology of acute GVHD is complex and can be conceptualized to be a three-step process based on murine studies. In step 1, the conditioning regimen le
The biologic basis of Graft-Versus-Host Disease (GVHD) is presented as an extremely complex immunopathologic syndrome that involves interaction between many different donor and host cell types. A model of acute lethal GVHD was employed where adult unirradiated (DA X LEW)F1 rats were injected with LE