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Pharmacologic intervention in ischemia-induced reperfusion injury in the skeletal muscle

✍ Scribed by Cho Y. Pang; Christopher R. Forrest; Robert Mounsey

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
718 KB
Volume
14
Category
Article
ISSN
0738-1085

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✦ Synopsis

Abstract

This article provides a concise review on the potential causes of ischemia‐induced reperfusion (I/R) injury and pharmacologic intervention in the skeletal muscle. Special emphasis is placed on the recent observation of the acute ischemic preconditioning phenomenon for prevention of I/R injury in skeletal muscle. Finally, the mechanism of ischemic preconditioning and its clinical applications for augmentation of skeletal muscle tolerance to prolonged ischemic insult are discussed. © 1993 Wiley‐Liss Inc.

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