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Pharmacokinetics, Tissue Distribution and Excretion of Recombinant Human Parathyroid Hormone 1–84 in Animals

✍ Scribed by Hua Bai, Danqing Jing, Hua Jiang, Shinan Yin

Book ID
120897768
Publisher
Springer-Verlag
Year
2013
Tongue
English
Weight
459 KB
Volume
66
Category
Article
ISSN
1085-9195

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✍ Karen O. Jones; Godfried Owusu-Ababio; Andrew M. Vick; M. Amin Khan 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 129 KB

The pharmacokinetics (PK) and hepatic extraction (E(H)) of human PTH (1-34), hPTH (1-34), were characterized in rat, dog, and monkey, following intraportal (IPO) and intravenous (IV) bolus administration. hPTH (1-34) was administered to Sprague-Dawley rats (2, 10, 100 microg/kg), beagle dogs (3, 6 m