Pharmacokinetics of β-methyldigoxin in healthy humans IV: Comparisons of radioimmunoassays, total radioactivity, and specific assays of β-methyldigoxin and digoxin in plasma
✍ Scribed by Edward R. Garrett; Peter H. Hinderling
- Publisher
- John Wiley and Sons
- Year
- 1977
- Tongue
- English
- Weight
- 488 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0022-3549
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Digoxin and beta-methyldigoxin were evaluated pharmacokinetically in terms of P-glycoprotein (P-gp)-mediated drug interactions in rats. Evaluation was made by measuring the effects of a potent P-gp inhibitor (verapamil, cyclosporin A) on in vitro efflux transport of these compounds across the everte
Recently, we found that potent P-glycoprotein (P-gp) inhibitors, such as verapamil and cyclosporin A, markedly modulated the pharmacokinetics of digoxin in rats, whereas they did not affect b-methyldigoxin pharmacokinetics significantly. Digoxin is also a substrate of rat organic anion transporting