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Pharmacokinetics of torasemide and its metabolites in healthy controls and in chronic renal failure

✍ Scribed by H. Spahn; H. Knauf; E. Mutschler

Publisher
Springer
Year
1990
Tongue
English
Weight
344 KB
Volume
39
Category
Article
ISSN
0031-6970

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✦ Synopsis

The pharmacokinetics of 20 mg torasemide i.v. has been studied in 7 healthy controls and 9 patients with varying degrees of renal impairment. Torasemide had a t1/2 of about 4h which was independent of kidney function, as the nonrenal clearance of torasemide was 3-times greater than its renal clearance. The active metabolite M 1 and the main metabolite M 5 were accumulated in chronic renal failure. In contrast to liver function, therefore, kidney failure does not have an important effect on the pharmacokinetics of torasemide.

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